Most of the experts from Africa and Europe behind this project have already successfully worked together in the two previous EDCTP-funded initiatives AE-TBC (“African European Tuberculosis Consortium”, July 2010 - December 2013) and ScreenTB (“Evaluation of host biomarker-based point-of-care tests for targeted screening for active TB”, April 2016 – July 2019). They have now teamed up with the Foundation of Innovative New Diagnostics (FIND) to further improve the test and ensure its global applicability and prepare its commercialization.
Core activities overview
WP1

Global Signature Multi-Biomarker Test strip for POC TB Triage using Fingerstick Blood

Lead: Leiden University Medical Center (LUMC)

WP1 will refine the biomarker signature on the MBT strip for global application and integrate it in test strips which are then evaluated in a large prospective study on fresh fingerstick blood in WP2.

WP2

Field testing of MBT on FSB in laboratory-free manner

Stellenbosch University (SUN)

WP2 will compare the diagnostic performance of our test strips to the final composite diagnostic gold standard of clinical findings, chest X-ray, sputum microbiology and treatment response. This non-interventional clinical study will enrol adult participants in The Gambia, South Africa and Uganda.

WP3

Database management and analysis

Stellenbosch University (SUN)

WP3 will capture, manage and analyse clinical and laboratory data. The WP will assess biomarker performance, help select the best global biosignatures, and develop diagnostic algorithms that can be incorporated into the handheld readers.

WP4

Capacity Development and Networking

London School of Hygiene and Tropical Medicine (LSHTM)

WP4 will strengthen capacities of both scientific and administrative staff of all partner institutions. Structured mentoring and a focus on individual career development will support individuals to achieve their full potential.

WP5

Dissemination, Communication and Exploitation

LINQ Management GmbH (LINQ)

WP5 provides all necessary support to facilitate communication about the project, effective dissemination of its results, and optimal uptake and exploitation of project outcomes.

WP6

Project management

LINQ Management GmbH (LINQ)

This WP will provide all necessary support to enable a smooth and efficient project workflow.

Team

TriageTB is implemented by a team of passionate people with very complementary skills but one common goal: to make a real difference in the lives of patients.

They are combining their extensive experience in biomarker discovery, clinical research, assay development, commercialization, capacity development, networking and grant management to speed up and streamline how TB is diagnosed in resource-limited settings. Building on many years of joint research that has prepared this work, and with the Foundation of Innovative New Diagnostics (FIND) as a new partner by their side, the consortium is ready to make an impact.

Keeping our planet safe

In an international collaborative research project such as TriageTB, partners need to work together across countries and continents. A lot of work can be done individually, but to coordinate all activities properly the whole consortium needs to come together in person at least once a year, which unfortunately involves many long distance flights.

As our group is very concerned about the impact this has on our environment we have decided to offset the CO2 emissions of all the flights that are needed to implement this project. Following the global standardized framework of the Greenhouse Gas Protocol we will calculate our CO2 emissions. To offset them, we will select a Gold Standard certified project in one of the countries where we implement our clinical study, thus not only reducing our carbon footprint and offseting our unavoidable emissions, but also creating jobs and capacities in our African partner countries.

Latest News

COVID-19 Diagnostics and Testing Online Course launched

The Foundation for Innovative New Diagnostics (FIND) and the African Society for Laboratory Medicine (ASLM) have developed a free online course on COVID-19 diagnostics and testing.

TriageTB and the next generation of TB scientists

Building on the experience gained in previous joint projects, capacity strengthening is a central element in the TriageTB work plan and one of the project’s key objectives.

Newspaper article featuring the work of LUMC team

The work of TriageTB consortium members Dr Paul Corstjens and Professor Annemieke Geluk was featured in an article in the local Dutch newspaper Leidsch Dagblad on 4 December 2019.

Our latest publication

Keshavjee S, Amanullah F, Cattamanchi A,Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Hoi LV,Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL,Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E,Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, RustomjeeR, Nahid P.

Moving Toward Tuberculosis Elimination: Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection

Am J Respir Crit Care Med. 2019; 199(5):564-571.doi: 10.1164/rccm.201806-1053PP. PMID: 30335466
Read Publication